 |
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|---|---|---|
| 【ProductName】 |
TPX2 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K111082P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q9ULW0 |
|
| 【Gene ID】 |
22974 |
|
| 【Application】 |
Blocking Peptide of K111082P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at ’Thr-288’ and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis， GOLGA2 interacts with importin-alpha， liberating TPX2 from importin-alpha， allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.