 |
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|---|---|---|
| 【ProductName】 |
BCAR3 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K111291P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
O75815 |
|
| 【Gene ID】 |
8412 |
|
| 【Application】 |
Blocking Peptide of K111291P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
|
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Background：
Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation， migration， and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1， involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion， actin filament rearrangement， and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling， via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity， potentially via regulation of focal adhesion complex signaling (