 |
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|---|---|---|
| 【ProductName】 |
WDR41 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K113560P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q9HAD4 |
|
| 【Gene ID】 |
55255 |
|
| 【Application】 |
Blocking Peptide of K113560P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Non-catalytic component of the C9orf72-SMCR8 complex， a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190， PubMed:27103069， PubMed:27617292， PubMed:28195531).The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP， converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form， thereby promoting autophagosome maturation (PubMed:27103069).As part of the C9orf72-SMCR8 complex， stimulates RAB8A and RAB11A GTPase activity in vitro， however WDR42 is shown not be an essential complex component for this function (PubMed:32303654).The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069， PubMed:27617292).