Background：

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi， and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region， including a specific mutation that changes an ATG start codon to AGG， have been reported in a variety of solid tumors; however， these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.