Background：

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2，6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2，6-biphosphate using independent catalytic domains. Fructose-2，6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently， regulating fructose-2，6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq， Nov 2012]