Anti-LRRC25 Polyclonal Antibody - RBITC
Cat: K112410P - RBITC
Summary:
| 【Product name】：Anti-LRRC25 Polyclonal Antibody - RBITC | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：126364 | 【Swiss Prot】：Q8N386 |
| 【Tested applications】：WB ELISA IHC ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human LRRC25 | |
| 【Public Immunogen Range】：1-101aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164).Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
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