Anti-CRACR2A Polyclonal Antibody - SAlexa Fluor 660
Cat: K112469P - SAlexa Fluor 660
Summary:
| 【Product name】：Anti-CRACR2A Polyclonal Antibody - SAlexa Fluor 660 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：84766 | 【Swiss Prot】：Q9BSW2 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human CRACR2A | |
| 【Public Immunogen Range】：1-335aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Ca2+-binding protein that plays a key role in store-operated Ca2+ entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+ resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
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