Anti-HSF1 Polyclonal Antibody - SAlexa Fluor 647
Cat: K010070P - SAlexa Fluor 647
Summary:
| 【Product name】：Anti-HSF1 Polyclonal Antibody - SAlexa Fluor 647 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：3297 | 【Swiss Prot】：Q00613 |
| 【Observed】：83kDa | |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human HSF1 | |
| 【Public Immunogen Range】：230-529aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
HSF1 belongs to heat-shock transcription factor that activate heat-shock response genes under conditions of heat or other stresses. Also, HSF1 has linked with oogenesis, spermatogenesis, and placental development. It can activate AKT and inactivate JNK and CASP3 to protect cardiomyocytes from death. And it has a role in the regulation of life span and establishs a role for SIRT1 in protein homeostasis and heat-shock response. The calculated molecular weight of HSF1 is 57 kDa, but HSF1 migrates at approximately 80 kDa that likely represent different phosphorylation states (PMID: 18434628).
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