Anti-TNFRSF1B Polyclonal Antibody
Cat: K112705P
Summary:
| 【Product name】：Anti-TNFRSF1B Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：7133 | 【Swiss Prot】：P20333 |
| 【Observed】：50kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human TNFRSF1B | |
| 【Public Immunogen Range】：30-250aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Verified picture:
Western blot analysis with TNFRSF1B antibody diluted at 1:2000;Lane: MCF7,293T,U937.
Immunohistochemistry of paraffin-embedded human colorectal cancer with TNFRSF1B antibody diluted at 1:100.