Anti-ARRDC1 Polyclonal Antibody - Cy3.5
Cat: K112712P - Cy3.5
Summary:
| 【Product name】：Anti-ARRDC1 Polyclonal Antibody - Cy3.5 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：92714 | 【Swiss Prot】：Q8N5I2 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:25-100. | |
| 【Immunogen】：Recombinant protein of human ARRDC1 | |
| 【Public Immunogen Range】：81-434aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940).
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