Anti-ITM2C Polyclonal Antibody - FITC
Cat: K112719P - FITC
Summary:
| 【Product name】：Anti-ITM2C Polyclonal Antibody - FITC | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：81618 | 【Swiss Prot】：Q9NQX7 |
| 【Observed】：70kDa | |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human ITM2C | |
| 【Public Immunogen Range】：1-200aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
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