Anti-ITM2C Polyclonal Antibody - SAlexa Fluor 594
Cat: K112720P - SAlexa Fluor 594
Summary:
| 【Product name】：Anti-ITM2C Polyclonal Antibody - SAlexa Fluor 594 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：81618 | 【Swiss Prot】：Q9NQX7 |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human ITM2C | |
| 【Public Immunogen Range】：1-200aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
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