Anti-SIK3 Polyclonal Antibody
Cat: K112764P
Summary:
| 【Product name】：Anti-SIK3 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：23387 | 【Swiss Prot】：Q9Y2K2 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:25-100. | |
| 【Immunogen】：A synthetic peptide of Human SIK3 | |
| 【Public Immunogen Range】：1125-1175/1321aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230).Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).
Verified picture:
Immunohistochemistry of paraffin-embedded human colorectal cancer with SIK3 antibody diluted at 1:50.