下载
Anti-ALK Polyclonal Antibody - SAlexa Fluor 640
Cat: K112773P - SAlexa Fluor 640
Summary:
【Product name】:Anti-ALK Polyclonal Antibody - SAlexa Fluor 640 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:238 【Swiss Prot】:Q9UM73
【Tested applications】:IHC
【Recommended dilution】:IHC 1:25-100.
【Immunogen】:A synthetic peptide of Human ALK
【Public Immunogen Range】:1500-1550/1620aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).
Verified picture: