Anti-BCOR Polyclonal Antibody
Cat: K112785P
Summary:
| 【Product name】：Anti-BCOR Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：54880 | 【Swiss Prot】：Q6W2J9 |
| 【Observed】：107kDa | |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:1000-3000. | |
| 【Immunogen】：A synthetic peptide of Human BCOR | |
| 【Public Immunogen Range】：730-780/1755aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
Verified picture:
Western blot analysis with BCOR antibody diluted at 1:2000;Lane: HeLa,HEK293,K-562,HEL,PC-3M-IE8,T47d,A549.