Anti-DENND2B Polyclonal Antibody - SAlexa Fluor 750
Cat: K112812P - SAlexa Fluor 750
Summary:
| 【Product name】：Anti-DENND2B Polyclonal Antibody - SAlexa Fluor 750 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6764 | 【Swiss Prot】：P78524 |
| 【Observed】：72kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:2000-5000. IHC 1:25-100. | |
| 【Immunogen】：A synthetic peptide of human DENND2B | |
| 【Public Immunogen Range】：505-555/1137aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008].
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