Anti-Tyk 2 Polyclonal Antibody
Cat: K112824P
Summary:
| 【Product name】：Anti-Tyk 2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：7297 | 【Swiss Prot】：P29597 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:25-100. | |
| 【Immunogen】：A synthetic peptide of human Tyk 2 | |
| 【Public Immunogen Range】：270-320/1187aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Verified picture:
Immunohistochemistry of paraffin-embedded human renal cancer with Tyk 2 antibody diluted at 1:50.