Anti-ELAC2 Polyclonal Antibody
Cat: K112854P
Summary:
| 【Product name】：Anti-ELAC2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：60528 | 【Swiss Prot】：Q9BQ52 |
| 【Observed】：100kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:2000-5000. IHC 1:25-100. | |
| 【Immunogen】：Recombinant protein of human ELAC2 | |
| 【Public Immunogen Range】：1-350aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Verified picture:
Western blot analysis with ELAC2 antibody diluted at 1:3000;Lane: HepG2,MCF7,HeLa,293T,Jurkat.
Immunohistochemistry of paraffin-embedded human thyroid cancer with ELAC2 antibody diluted at 1:50.