Anti-POLQ Polyclonal Antibody
Cat: K112920P
Summary:
| 【Product name】：Anti-POLQ Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：10721 | 【Swiss Prot】：O75417 |
| 【Observed】：240kDa | |
| 【Tested applications】：WB,ELISA,IHC | |
| 【Recommended dilution】：WB 1:2000-5000. IHC 1:25-100. | |
| 【Immunogen】：A synthetic peptide of human POLQ | |
| 【Public Immunogen Range】：2430-2480/2590aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323).MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323).POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963).
Verified picture:
Immunohistochemistry of paraffin-embedded Human breast cancer with POLQ antibody diluted at 1:50.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with POLQ antibody diluted at 1:50.