Anti-POLQ Polyclonal Antibody - SAlexa Fluor 350
Cat: K112920P - SAlexa Fluor 350
Summary:
| 【Product name】：Anti-POLQ Polyclonal Antibody - SAlexa Fluor 350 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：10721 | 【Swiss Prot】：O75417 |
| 【Observed】：240kDa | |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human POLQ | |
| 【Public Immunogen Range】：2430-2480/2590aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323).MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323).POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963).
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