Anti-KPTN Polyclonal Antibody
Cat: K112970P
Summary:
| 【Product name】：Anti-KPTN Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：11133 | 【Swiss Prot】：Q9Y664 |
| 【Observed】：54kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human KPTN | |
| 【Public Immunogen Range】：1-350aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Verified picture:
Western blot analysis with KPTN antibody diluted at 1:2000;Lane: NIH3T3,SH-SY5Y,Mouse skeletal muscle,HepG2.
Immunohistochemistry of paraffin-embedded human renal cancer with KPTN antibody diluted at 1:100.