Anti-Caspase 1/p20/p10 Polyclonal Antibody
Cat: K010101P
Summary:
| 【Product name】：Anti-Caspase 1/p20/p10 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：834 | 【Swiss Prot】：P29466 |
| 【Tested applications】：WB,IHC,ELISA,IF | |
| 【Recommended dilution】：WB 1:500-2000. IHC 1:100-400. IF 1:10-100. | |
| 【Immunogen】：Recombinant protein of human Caspase 1/p20/p10 | |
| 【Public Immunogen Range】：1-311aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020). It has 5 isoforms produced by alternative splicing. It can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20.
Verified picture:
Western blot analysis with Caspase 1/p20/p10 antibody diluted at 1:1000;Lane: Raw264.7.
Immunohistochemistry of paraffin-embedded human spleen with Caspase 1/p20/p10 antibody diluted at 1:200.
Immunofluorescence analysis of C6 cells using Caspase 1/p20/p10 antibody diluted at 1:50.