Anti-POLE Polyclonal Antibody - SAlexa Fluor 555
Cat: K113101P - SAlexa Fluor 555
Summary:
| 【Product name】：Anti-POLE Polyclonal Antibody - SAlexa Fluor 555 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：5426 | 【Swiss Prot】：Q07864 |
| 【Observed】：262kDa | |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human POLE | |
| 【Public Immunogen Range】：360-410/2286aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849).Participates in chromosomal DNA replication (By similarity).Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity).Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity).Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199).Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374).
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