Anti-RANGRF Polyclonal Antibody - SAlexa Fluor 647
Cat: K113151P - SAlexa Fluor 647
Summary:
| 【Product name】：Anti-RANGRF Polyclonal Antibody - SAlexa Fluor 647 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：29098 | 【Swiss Prot】：Q9HD47 |
| 【Observed】：24kDa | |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human RANGRF | |
| 【Public Immunogen Range】：130-180/186aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
May regulate the intracellular trafficking of RAN (PubMed:11290418).Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603).Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603).Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375).
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