Anti-THOC7 Polyclonal Antibody
Cat: K113168P
Summary:
| 【Product name】：Anti-THOC7 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：80145 | 【Swiss Prot】：Q6I9Y2 |
| 【Observed】：26kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:2000-5000. IHC 1:25-100. | |
| 【Immunogen】：A synthetic peptide of human THOC7 | |
| 【Public Immunogen Range】：100-150/204aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.
Verified picture:
Immunohistochemistry of paraffin-embedded human breast cancer with THOC7 antibody diluted at 1:50.
Western blot analysis with THOC7 antibody diluted at 1:3000;Lane: THP-1,U-937,Mouse testis.