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Anti-TMEM147 Polyclonal Antibody - SAlexa Fluor 680
Cat: K113174P - SAlexa Fluor 680
Summary:
【Product name】:Anti-TMEM147 Polyclonal Antibody - SAlexa Fluor 680 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:10430 【Swiss Prot】:Q9BVK8
【Observed】:30kDa
【Tested applications】:WB
【Recommended dilution】:WB 1:1000-3000.
【Immunogen】:A synthetic peptide of human TMEM147
【Public Immunogen Range】:50-100/224aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Component of a ribosome-associated endoplasmic reticulum (ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity. Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity.
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