Anti-RNF170 Polyclonal Antibody
Cat: K113200P
Summary:
| 【Product name】：Anti-RNF170 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：81790 | 【Swiss Prot】：Q96K19 |
| 【Observed】：22kDa | |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:2000-5000. IHC 1:25-100. | |
| 【Immunogen】：A synthetic peptide of human RNF170 | |
| 【Public Immunogen Range】：150-200/258aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene.
Verified picture:
Immunohistochemistry of paraffin-embedded human colorectal cancer with RNF170 antibody diluted at 1:50.
Western blot analysis with RNF170 antibody diluted at 1:3000;Lane: HEL,A431.