Anti-CYP2U1 Polyclonal Antibody
Cat: K113248P
Summary:
| 【Product name】：Anti-CYP2U1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：113612 | 【Swiss Prot】：Q7Z449 |
| 【Observed】：62kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human CYP2U1 | |
| 【Public Immunogen Range】：140-490aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates (PubMed:14660610, PubMed:24563460).Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:14660610, PubMed:24563460).Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (PubMed:14660610, PubMed:24563460).May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin (PubMed:24
Verified picture:
Western blot analysis with CYP2U1 antibody diluted at 1:2000;Lane: HeLa,U251,U87,T47d.
Immunohistochemistry of paraffin-embedded human colorectal cancer with CYP2U1 antibody diluted at 1:100.