Anti-CD33 Polyclonal Antibody
Cat: K113300P
Summary:
| 【Product name】：Anti-CD33 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：945 | 【Swiss Prot】：P20138 |
| 【Observed】：66kDa | |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:1000-3000. | |
| 【Immunogen】：A synthetic peptide of human CD33 | |
| 【Public Immunogen Range】：280-330/364aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.
Verified picture:
Western blot analysis with CD33 antibody diluted at 1:2000;Lane: U937,THP-1,HEL,U-87MG.