Anti-F2 Polyclonal Antibody - SAlexa Fluor 555
Cat: K113478P - SAlexa Fluor 555
Summary:
| 【Product name】：Anti-F2 Polyclonal Antibody - SAlexa Fluor 555 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：2147 | 【Swiss Prot】：P00734 |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human F2 | |
| 【Public Immunogen Range】：275-325/622aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants.
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