Anti-SIGIRR Polyclonal Antibody
Cat: K113503P
Summary:
| 【Product name】：Anti-SIGIRR Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：59307 | 【Swiss Prot】：Q6IA17 |
| 【Observed】：51kDa | |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:1000-3000. | |
| 【Immunogen】：A synthetic peptide of human SIGIRR | |
| 【Public Immunogen Range】：295-345/410aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Verified picture:
Western blot analysis with SIGIRR antibody diluted at 1:2000;Lane: Jurkat,Raji,MCF7,A549,U937,293T.