Anti-RIPK1 Polyclonal Antibody
Cat: K113613P
Summary:
| 【Product name】：Anti-RIPK1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：8737 | 【Swiss Prot】：Q13546 |
| 【Observed】：77kDa | |
| 【Tested applications】：IF,IHC,WB,ELISA | |
| 【Recommended dilution】：WB 1:2000-5000. IHC 1:25-100. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of human RIPK1 | |
| 【Public Immunogen Range】：170-520aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:32657447, PubMed:31827280, PubMed:31827281).Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283).Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity).
Verified picture:
Western blot analysis with RIPK1 antibody diluted at 1:3000;Lane: HeLa,HEL.
Immunohistochemistry of paraffin-embedded Human endometrial cancer with RIPK1 antibody diluted at 1:50.