Anti-DARPP32/PPP1R1B Polyclonal Antibody - Cy5.5
Cat: K010195P - Cy5.5
Summary:
| 【Product name】：Anti-DARPP32/PPP1R1B Polyclonal Antibody - Cy5.5 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：84152 | 【Swiss Prot】：Q9UD71 |
| 【Observed】：32kDa | |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human DARPP32/PPP1R1B | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP32) , also known as protein phosphatase 1 regulatory subunit 1B (PPP1R1B), is a substrate of cAMP-dependent protein kinase (PKA) enriched in dopamine-innervated brain areas. Overexpression of DARPP32 has been shown to block gefitinib-induced apoptosis in gastric tumors by promoting EGFR and ERBB3 heterodimerization (PMID: 21741919). DARPP32 also drives gefitinib-refractory lung tumor growth through similar ERBB3-mediated resistance mechanisms(PMID: 34675407).
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