Anti-PRKAA1/PRKAA2 Polyclonal Antibody
Cat: K113855P
Summary:
| 【Product name】：Anti-PRKAA1/PRKAA2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：5562/5563 | 【Swiss Prot】：Q13131/P54646 |
| 【Observed】：65kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human PRKAA1/PRKAA2 | |
| 【Public Immunogen Range】：150-200/559aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Verified picture:
Immunohistochemistry of paraffin-embedded human pancreatic cancer with PRKAA1/PRKAA2 antibody diluted at 1:100.
Western blot analysis with PRKAA1/PRKAA2 antibody diluted at 1:2000;Lane: MCF7,A549,NIH3T3.