Anti-TXNIP Polyclonal Antibody
Cat: K113876P
Summary:
| 【Product name】：Anti-TXNIP Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：10628 | 【Swiss Prot】：Q9H3M7 |
| 【Observed】：50kDa | |
| 【Tested applications】：WB,IF,IHC | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. IF 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human TXNIP | |
| 【Public Immunogen Range】：225-275/391aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants.
Verified picture:
Immunohistochemistry of paraffin-embedded human ovarian cancer with TXNIP antibody diluted at 1:100.
Western blot analysis with TXNIP antibody diluted at 1:2000;Lane: COLO205,NIH3T3.