Anti-GCLM Polyclonal Antibody
Cat: K113914P
Summary:
| 【Product name】：Anti-GCLM Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：2730 | 【Swiss Prot】：P48507 |
| 【Observed】：33kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human GCLM | |
| 【Public Immunogen Range】：30-80/274aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Verified picture:
Immunohistochemistry of paraffin-embedded human breast cancer with GCLM antibody diluted at 1:100.
Western blot analysis with GCLM antibody diluted at 1:2000;Lane: Mouse kidney.