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Anti-CASP4/CASP5 Polyclonal Antibody - SAlexa Fluor 405
Cat: K113925P - SAlexa Fluor 405
Summary:
【Product name】:Anti-CASP4/CASP5 Polyclonal Antibody - SAlexa Fluor 405 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:837/838 【Swiss Prot】:P49662/P51878
【Tested applications】:IHC
【Recommended dilution】:IHC 1:50-200.
【Immunogen】:A synthetic peptide of human CASP4/CASP5
【Public Immunogen Range】:240-290/377aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
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