Anti-Phospho-IRE1(Ser724) Polyclonal Antibody - RBITC
Cat: K010546P - RBITC
Summary:
| 【Product name】：Anti-Phospho-IRE1(Ser724) Polyclonal Antibody - RBITC | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：2081 | 【Swiss Prot】：O75460 |
| 【Observed】：130kDa | |
| 【Tested applications】：WB ELISA IHC ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human Phospho-IRE1(Ser724) | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
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