Anti-ATP7A Polyclonal Antibody - SAlexa Fluor 350
Cat: K010466P - SAlexa Fluor 350
Summary:
| 【Product name】：Anti-ATP7A Polyclonal Antibody - SAlexa Fluor 350 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：538 | 【Swiss Prot】：Q04656 |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human ATP7A | |
| 【Public Immunogen Range】：242-285/1500aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Copper-transporting ATPase 1 is an integral membrane protein cycling constitutively between the trans-golgi network and the plasma membrane. It may supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells. Defects in ATP7A are the cause of Menkes syndrome; also known as kinky hair disease, an X-linked recessive disorder.
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