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Anti-CSNK1G2 Polyclonal Antibody - SAlexa Fluor 647
Cat: K114129P - SAlexa Fluor 647
Summary:
【Product name】:Anti-CSNK1G2 Polyclonal Antibody - SAlexa Fluor 647 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:1455 【Swiss Prot】:P78368
【Observed】:43kDa
【Tested applications】:FC ICC IF
【Recommended dilution】:Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of human CSNK1G2
【Public Immunogen Range】:300-350/415aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
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