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Anti-MDH1 Polyclonal Antibody - RBITC
Cat: K114117P - RBITC
Summary:
【Product name】:Anti-MDH1 Polyclonal Antibody - RBITC 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:4190 【Swiss Prot】:P40925
【Observed】:37kDa
【Tested applications】:WB ELISA IHC ICC IF
【Recommended dilution】:ICC 1:50-200. IF 1:50-200
【Immunogen】:Recombinant protein of human MDH1
【Public Immunogen Range】:1-335aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6.
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