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Anti-ARID4B Polyclonal Antibody - SAlexa Fluor 660
Cat: K114141P - SAlexa Fluor 660
Summary:
【Product name】:Anti-ARID4B Polyclonal Antibody - SAlexa Fluor 660 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:51742 【Swiss Prot】:Q4LE39
【Observed】:265kDa
【Tested applications】:WB
【Recommended dilution】:WB 1:500-2000.
【Immunogen】:A synthetic peptide of human ARID4B
【Public Immunogen Range】:1175-1225/1312aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).
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