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Anti-PLCZ1 Polyclonal Antibody - HRP
Cat: K114085P - HRP
Summary:
【Product name】:Anti-PLCZ1 Polyclonal Antibody - HRP 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:89869 【Swiss Prot】:Q86YW0
【Observed】:65kDa
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200
【Immunogen】:Recombinant protein of human PLCZ1
【Public Immunogen Range】:60-340aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
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