Anti-RSPO1 Polyclonal Antibody
Cat: K114063P
Summary:
| 【Product name】：Anti-RSPO1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：284654 | 【Swiss Prot】：Q2MKA7 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human RSPO1 | |
| 【Public Immunogen Range】：1-264aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants.
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