Anti-DPPA3 Polyclonal Antibody - SAlexa Fluor 680
Cat: K114014P - SAlexa Fluor 680
Summary:
| 【Product name】：Anti-DPPA3 Polyclonal Antibody - SAlexa Fluor 680 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：400206 | 【Swiss Prot】：Q6W0C5 |
| 【Observed】：17kDa | |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:200-1000. | |
| 【Immunogen】：Recombinant protein of human DPPA3 | |
| 【Public Immunogen Range】：1-160aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation.
Verified picture: