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Anti-COX4I2 Polyclonal Antibody
Cat: K114657P
Summary:
【Product name】:Anti-COX4I2 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:84701 【Swiss Prot】:Q96KJ9
【Observed】:17kDa
【Tested applications】:WB
【Recommended dilution】:WB 1:500-2000.
【Immunogen】:A synthetic peptide of human COX4I2
【Public Immunogen Range】:10-60/171aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4
Verified picture:
Western blot analysis with COX4I2 antibody diluted at 1:1000;Lane: MCF7,A375,NIH3T3.