Anti-CMTM6 Polyclonal Antibody - SAlexa Fluor 532
Cat: K114661P - SAlexa Fluor 532
Summary:
| 【Product name】：Anti-CMTM6 Polyclonal Antibody - SAlexa Fluor 532 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：54918 | 【Swiss Prot】：Q9NX76 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human CMTM6 | |
| 【Public Immunogen Range】：133-183/183aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
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