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Anti-SMC1B Polyclonal Antibody
Cat: K114767P
Summary:
【Product name】:Anti-SMC1B Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:27127 【Swiss Prot】:Q8NDV3
【Observed】:150kDa
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:1000-3000.IHC 1:50-200.
【Immunogen】:Recombinant protein of human SMC1B
【Public Immunogen Range】:140-490aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
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