Potent pro-inflammatory cytokine Initially discovered as the major endogenous pyrogen，induces prostaglandin synthesis，neutrophil influx and activation，T-cell activation and cytokine production，B-cell activation and antibody production，and fibroblast proliferation and collagen production Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.