Anti-EPOR Polyclonal Antibody - Biotin
Cat: K114353P - Biotin
Summary:
| 【Product name】：Anti-EPOR Polyclonal Antibody - Biotin | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：2057 | 【Swiss Prot】：P19235 |
| 【Observed】：48kDa | |
| 【Tested applications】：WB ELISA IHC ICC | |
| 【Recommended dilution】：WB 1:50-200. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human EPOR | |
| 【Public Immunogen Range】：10-60/508aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding，this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase，phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
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